If it comes down to a
fixed bridge, the 7421 is JUST AS GOOD as the 7621. I've played many 7621's and none of them did I see a $250 dollar worth improvement.
Plus the 7621 is discounted anyway. Unless your REALLY picky about your hardware, because they do have different bridges. The 7621 has the GTC which is a high-end standard fixed bridge. The GTC-Jr. is considered a more mid-range quailty fixed bridge but to me it couldnt be any better. Stays in tune great and sounds great.
P.S- This is assuming changing p/u's to whatever you perfer. I wouldn't perfer the New-7's OR the Ibanez so I'm not taking that into account.