The original Fender single coil stagger was for a wound G. So the balance from string to string is more appropriate with a wound G. But almost every modern guitar hero uses/used a plain G, so don't take that to mean "better."
The split between wound and unwound strings is dramatic. Not just in feel, but in tone, volume, and intonation. If you look on a standard bridge there's sort of a separation to the intonation. From the high E down it goes: "close/mid/far/close/mid/far." If you look at a compensated acoustic saddle it's: "close/far/close/mid/mid/far." The wound G no longer is the most "intonation sensitive," and therefore farthest back of the top three, rather it is less sensitive, and closer forward like where the D is. So your intonation will need to be adjusted, much more than just changing gauges of plain strings.
Bends on the wound G will be less responsive. You'll have to bend farther to reach the same pitch as a plain G. Finally back to the pickup stagger, you may find yourself raising adjustable poles under the G like Fender singles, to make it more audible against the other strings. A long time ago I thought I'd like a wound G and I didn't.