Well, I got my idea from Brian May, when I first saw his Star Licks instructional video years ago.
He uses a treble booster. See this video, from 3:20 onward:
http://www.youtube.com/watch?v=36fI7Y2-sZA
When I got my first tube amp, I got that 'confused noise', and I remembered Brian May's treble booster. Worked like a charm for me. And I've also tried it on multifx/modelers since then. With some of the amp models, putting a treble booster in front works quite well. On the Pod, the FX Boost + Eq effect can do that trick. You could also use a Tube Screamer for example.