I've got a Laney GH50L that I run through an Orange PPC212 cab and the distortion is incredible without any pedals. I used my DS-1 with it once or twice and it didn't make a difference really.
If the distortion on the amp that you get isn't sufficient, use a tubescreamer with it, maybe with a Keeley mod like rastachild. I was shown a modded TS9 before on a JCM800 and it made so much difference in comparison to an unmodded TS9. I'd get one but I can't afford it!
I like to keep my amp sound as pure as possible, apart from effects like reverb/delay. As convinient as pedals are, I prefer not to use them - unless it's a modded TS9 of course!
