I've used a Boss GX700 with a FC200
midi footcontroller for years. Basically dozens of pedals in a 19" box. Been very happy with that.
Recently switched to a Boss GT Pro. Mainly because of the larger flexibility in the midi department and newer amp models (think Rectifier), added bonus is various extra ways you can hook it up (balanced outputs, USB and optical connection to your pc for editing and recording). Together with a stereo
power amp (solid state) and either 2 wedge monitors or 4x12's this is my personaly preferred, lightweight, multi-purpose, live-rig.