F spacing is done to help get those magnetic poles as dead on under the
strings as possible. Here is what DiMarzio has to say about it:
F-SPACING:
F-spacing refers to a wider spacing between pole pieces available upon request at no extra charge on all full-sized humbuckers. For proper string alignment and balanced output, F-spaced humbuckers should be used in the
bridge position on all guitars with string spacing of 2.1" (53 mm) or greater. This applies to most guitars with tremolos, as well as many newer fixed-bridge instruments. On guitars with a nut width of 1-11/16" (43 mm) or greater, F-spaced pickups can be used in the
neck position as well. Please specify "F-spaced" at the time you place your order.
(IMHO) I buy all my pickups F spaced. You never know when you can
used the pickup elsewhere in the future, and it doesn't cost anything
extra to buy one F spaced.
The only time I wouldn't buy an F spaced, is if you have a narrow bridge,
nut, and or neck like on the vintage strats, Alvarez electrics, and some
Jacksons. But even then, F spacing does pretty well.