I voted "it depends". I think that there are so many ways these days to get a distorted tone, woods, pickups, pre-amps, pedals, amps and volume are just some of them.
Thus if you run a triple rectifier dialled all the way up, with a DS-1 in front of it and a boosted graphic equalizer, then a high output pickup might not be what you need. Alternatively if you're running straight into an old Marshall 1959 with no effects, you might want a little more umph straight from the guitar.
sometimes tho i found that its easier to remove some of the charachteristics and dynamics and tone from a high gain pickup rather than to have a low gain pup and trying to boost it
i can make my x2n sound closer to a evo, than making my evo sound like a x2n
also high gain pickups also offer characteristics wich can sometimes be of a good note, for instance some pickups have a higher natural compression....when in fact others dont
for instance if i send my duncan distortion or evo or breed into a noice gate, compressor limiter(etc)...i can actually hear the compression in a active state
if i send my x2n through my noise gate...i can almost never need a compresor for it
the dynamics it introduces into my preamp, are different than others, even when i had a carvin and i used duncan distortions in it before i got bartolini's, i had it go though a noise gate, compressor, eq and etc.... and it took all that to get me to my sound, but with a x2n i get what i want stock, and more, and i also can really fine tune the sound, cuz i just remove the frequencies i want or the charachterisits i want to emply on my signal, and i get a thick sustained tone
ive used a few preamps, but now i use a 2120 artist