I give you my vote for the EMG 707.
I put one in my RG7420. Yes, it did require some routing. But nothing a dremel couldn't handle really. Just take your time and don't forget to make room for the wire harness underneath the pickup.
It really depends on your style of music though. If you are into metal and such, it is great. Nice and clean with not a lot of noise or interference. I do hear what some people call the "sterile" or "artificial" sound. There is a certain frequency up in the 1.6-3khz range that is a little annoying but it is nothing that a good GE-7 EQ pedal can't handle. Just drop a touch and you are good to go. The GE-7 was one of the best bangs for my buck for sure. It's super nice to record with too and sounds great through a POD. I'm recording my band's album right now and I have some great results with it. I can post a link sometime if you want to hear a sample.
They are active pickups and require a 9 volt battery. But it will usually go for months and months before it goes dead (remember not to leave your chord plugged into the guitar). I think I've only used 2 batteries in one year. You also have to replace your potentiometers for volume and tone as well. But this is no big deal. They come with the pickup.
EMG's tech support was great. They sent me a custom wiring diagram especially for my guitar that helped me get it done faster.
When all was said and done, the 707 improved my sound over the ****ty stock pickup by about 10,000%. It was worth my time and money for sure.