Re: Possible upgrade options on prs se bernie marsden
If there's ever a certain guitar you like, regardless of price but you can afford it--get it! Nothing wrong with upgrading pickups and hardware on any guitar--hell, most of us do that all of the time!
Even top-of-the-line guitars may have pickups that you just don't dig. For example--the Ibanez Jem 7VWH. Some people just don't like the DiMarzio Evolutions and swap them out for different pickups.
The rule of thumb should be: if you like a guitar, then buy it. If you don't like some aspect of that guitar--change it.
I love all 30-something of my various Ibanez guitars, but I've swapped the pickups out of all of them for DiMarzios.
Buy what you like, and make it better if you can.