the rg421 was made for only 2 years and was replaced with the rg321. i had thought about getting a 421, but opted out because i don't like basswood. when the rg321mh came out, i was all over it. the mahogany closed the deal...although it is 3 piece mahogany and an "inferior" bridge. almost everything was the same spec-wise. the bound neck was a plus. i was going to swap the pickups anyway as all my rg's end up with air nortons and tone zones, so the pickups didn't matter. i really love my rg321. at the time i got mine i had not played one, but i knew what a wizard 2 felt like and the 421 had the same. the 421 seems only to be rarer due to the fact that it is discontinued, whereas the rg321 is in current production. also, the rg421 had a higher list on it and the rg321 is by far less expensive. the rg321, along with the artcores are just the best bang for the buck guitars i have owned in a long time. which ever of the 2 you get, though, you won't be disappointed. just right now, the rg321 would "make more sense".