I also play often through a 75W Line 6 Spider III.
If you need quite a bit of distortion, yet want to keep cords and soloing articulate and versatile, give a Seymour Duncan Distortion in the bridge a try. It works very well in alder/basswood body guitars. I have one in my Lag Rockline and love it for distorted sounds. Split in combination with a neck single coil or a split humbucker is very nice for percussive clean tones. The Seymour Duncan JB is fairly similar, but less hot.
As for Dimarzios, I can only speak for the AirNorton in the neck, as I know the ToneZone only in mahogany/maple top guitars.