It typically comes down to whether or not you're a Fender guy or a Gibson guy. Since pretty much all shred guitars are of Fender Strat DNA with the flat profile/low bridge that sits farther back on the top vs. Gibsons with the angled neck and higher bridge that sits forward on the top, it's easy to to understand why most people are either or.
I know I could learn to play a Paul and get used to it, but I never cared to because I was so comfortable with the flat Fender design. What Fender did ergonomicially (way back in the 50's when that sort of thing was not really a science) was nothing short of astonishing. The Les Paul and just about any semi-hollow guitar just feels super uncomfortable to me. Instead of innovating with the Les Paul, Gibson decided to make it a smaller, solid archtop just like they had been doing since their beginning (except for the solid part).
Plus, when you realize what Fender contributed to amplified music it makes Gibson pale in comparison...
1. Tube combo amps that worked reliably and sounded great
loud for the first time in the history of the guitar amp. The component design of these early amps went on to become the de-facto basis for many of today's popular amps... Marshall, Boogie, etc.
2. The Tele. Started it all. Without this innovative guitar we'd all be playing Jazz boxes right now.
3. The Les Paul was Gibson's answer to the Tele, which they initially laughed at and said would never sell. Fast forward a few years and they find themselves competing with the "boat paddle" Tele... so they release the Les Paul... and what does Fender do in the same year? They release the Sratocaster (the most popular and copied guitar in history) and the first ever ELECTRIC BASS guitar (yep, they invented it). lol! Poor Gibson. They've been behind ever since.
None of the above changes anything about the argument, but I just thought I'd share. I like the sound of Les Pauls, but I'm with Dee on the ergonomics... just can't get used to it and they are way too expensive to just have one laying around that barely gets played. Too much other stuff I want.