I play 10-46 at standard on another S I have. I like it. The 56 was just over the top for me. It didn't seem like the same guitar. Additionally, I have to wonder about the nut with such large strings. I had to raise the string tree considerably and the guitar just didn't seem happy. Beyond that, I had to crank the trem claw to the max and use an arrow pattern to get it to work. I don't block my trems and I'm not willing to install a 4th spring.
(1) 2006 S2170 9-42 at standard and occasionally drop D.
(1) 1997 S540FMTP 10-46 at standard.
(1) 1990 S540LTD 10-52 at Drop C.
Ive tried gauges 10-56 to 9-42 on them. I like the setup above the best. I can switch between guitars and still feel comfortable. Do they each feel differant? Of course.
Just my 2 pennies.
I tried the 10-56 combo after talking to torisho a few months ago. No offence, But I hated that setup. I tried to like it and kept it for bit. It just didn't work for me. Though, I must say I've seen torisho offer alot of GOOD information about things in the past/present so don't take it personally dude. (not that you would)
I may switch to 10-46 on the S2170 to accommodate drop D tuning better.
I'm not sure if I want to sacrafice the way that guitar plays. I like it the way it is in E standard. I'm sure I'll throw some 10-46's on it at some point.
One last thing, If your used to playing in E standard with 9-42's then your probably not going to like anything above 52 on the low E. Go find out for yourself. I did.