Whenever you get a new guitar, used or new, it's always a good idea to change the strings right away.
Go to www.ibanezrules.com
and look at Rich's tech section.
There's a great tutorial on there for complete setup.
You E string going off the side sounds like a neck alignment issue.
Can you post some pictures so we can see your guitar and how it's set up currently?
I've never hear the V1-V2 pickups, so I can't say, but I have read many, many times that they sound much better than the V7-V8 pickups used in RGs currently.
My two of my guitars came with aftermarket pickups, my third has the IBZ/Dimarzio pickups and contrary to what I've read about them, I really like them.
A good, proper setup is crucial to having a good playing, and good sounding guitar.
Change the strings, I'll bet your guitar will sound a lot better with a new set of strings.
Again, check the neck alignment. Both E strings should be about the same distance from the edges of the board, if one is close, or if it's much closer at the last fret compared to the first fret, your neck is out of line.
It's an easy fix. Just slightly loosen the neck bolts and tug gently on the neck in the direction opposite of the string that is too close to the edge. Check the alignment and repeat if needed. Tighten the bolts (don't go nuts, just tight enough to hold it still) and you should be good to go.