Re: Need help with mixing!
Definitely look up some guides online - you asked a very general question that has a wide range of answers lengthy answers for each instrument.
You are using an AXE-FX so I presume you are DIing and not using guitar cabs? I tend to find for guitar cabs HPF is your friend. You can cut a shelf out of a 70hz and below or so. For guitars and bass ( and when working with live drums for that matter ) there is nearly always something around the 150hz - 250hz area that can have a little notch taken out with a medium Q setting. Tends to be a lot of wool and resonance in and around there.
With vocals you can cut a bit out with your HPF too, and I usually find a sweet spot to put in a slight 1 or 2dB bump in the upper frequencies.
Above all, think about how each thing you are mixing is working with one another. ie, use Frequency/Spectrum analysers to look at what is happening where on your over all mix. For example, the bass guitar can become muddled up with the kick drum if the low end frequencies are all happening within a similar place. Just because you are using software drums, don't be afraid to look what they are doing within an analyser.
Also, use compression properly. Most tracks will require some form of compressor. I presume you are using plugins for this - some are more coloured than others. Find one with a good reputation and learn to use it properly, and not excessively. This will keep the levels of each track consistent and again, help with your clarity. You'll need it more so for things like bass guitar. Sometimes techniques like parallel compression is very useful for keep dynamics and controlling levels at the same time.
Don't over look your stereo out 2-track bus. This will effectively be your mastering section ie the area that you treat the over-all mix after you are happy with every individual track. Mild over all EQ, mild compression. To ensure clarity and to make use of your stereo depth, be sure you have looked at how each track is panned. Correct panning may seem obvious, but it can make the most of your mix by creating a wider image to work in. Many layers slapped on top of one another are very difficult to control.
After all this, if any sections are still being troublesome, don't be afraid to go into your track automation features and crank, dip or pan specific sections and lines.
Again, this is an extremely general guide of little pointers that I use on a daily basis in the recording studio I work at.
You can go much more in depth for each instrument, you just need to look up a summarised guide online. People have wrote entire series of books on this subject!