your best bet would be to try it through both and let your ears decide. a lot of the pros using those (dino cazares for example) run them into a tube poweramp, but alot of pros (meshuggah and weezer for example) are actually bypassing having amps and cabs at all and running them direct through the pa. i've never been much of a tube-head but i recently went to a rack set-up (from a johnson millenium 250 head) with a mesa 50/50 and it is killer! so yeah, try them out. preferably with your guitar and cab. that's probably very difficult, but i'd at least drag your podpro and guitar to the store and give both options a good run though! good luck!!!