Yeah, I do my drum sequencing in Fruity Loops. It's free, and once you get the hang of it you can get great results if you've got a good set of samples.
Generally, I try to keep the center of a mix free for the lead guitar (or your vocals, if that's what you're doing). double tracking and panning the guitars left and right is the best way to do this I've found, and it gives you a massive guitar sound, compared to a single track. So, I start with a stereo drum track, two tracks of guitar, usually panned at least 30% left and right. Bass a touch off to whatever side the kick drum isn't slightly off towards (we're talking tighter than 11/1 o'clock, only slightly off center). I don't generally record with kwys, but sometimes I'll harmonize, loop, and process the hell out of a few tracks of guitar to get a synth pad like sound, and i'll usually have that panned to sort of swirl around the mix subtly. Idunno, i just like the effect and sense of space it gives.
Also, correctly-used EQ and compression can help parts "sit" better- I generally roll off the bass below 120 or 160 Hz or so- right at the point where you can just BARELY hear a change in the low end if you're listening for it, but nothing that changes the "sound" of the guitar. This frees up room for the bass in the mix, so the two instruments don't "clash" in their frequency bands. this will, as unintuitive as it might seem, give you a fuller sounding low end. Likewise, if you compress the guitars, not to the point that you can hear any real audible difference but to smooth out the transient peaks, you'll be able to mix the track hotter before it clips, and even if you choose not to, it's best not to have it pushing 0dB if you don't have to.